Usually not outright. A visa-contingent closing, with funds in escrow released on issuance, keeps the investment committed for immigration purposes while protecting the buyer if the visa is refused. The sequence should be negotiated before the offer is signed.
Fix the order of events
Set the order as: due diligence, agreement with a visa-contingent closing and escrow, source-of-funds file, consular application, interview, issuance, release of funds, closing, arrival. Hypothetical example: a Lévis logistics coordinator negotiates to buy a U.S. freight-brokerage office.
The seller wants an unconditional close in sixty days; the buyer wants the visa first. The compromise that works for both is a deposit into escrow now, a purchase agreement whose only outstanding condition is visa issuance, and a closing date pegged to it. That shows commitment without exposing the buyer to owning a business she cannot enter the country to run.
Meanwhile the buyer should not start managing the business remotely from Lévis in any way that looks like unauthorised work, and should not sign a personal lease in the United States. Add current consular appointment wait times to the plan and tell the seller the realistic window honestly.